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銆銆涓汉绠浠

銆銆涓闄笂娴疯嵂鐗╂墍璇鹃缁勭粍闀匡紝鐮旂┒鍛橈紝鍗氬 2003骞村湪涓浗绉戝闄笂娴疯嵂鐗╃爺绌舵墍鑾峰緱鍗氬＋瀛︿綅锛2003-2005骞村湪鍔犳嬁澶cGill(楹﹀悏灏)澶у鍋氳闂爺绌躲備富瑕佸紑灞曞熀浜庣粨鏋/鐗囨鐨勮嵂鐗╄璁′笌鍚堟垚鐮旂┒銆

銆銆鐩墠鐮旂┒灏忕粍宸插缓璁惧畬鍠勮嵂鐗╁寲瀛︺佺粨鏋勭敓鐗╁銆佽绠楀寲瀛︾瓑澶氬绉戜氦鍙夌殑鐮旂┒骞冲彴锛岄拡瀵硅泲鐧界炕璇戝悗淇グ浣撶郴涓噸瑕佺殑婵閰躲佽〃瑙傞仐浼犺皟鎺ц泲鐧藉紑灞曞垱鏂拌嵂鐗╃爺鍙戙傝縿浠婂凡鍦ㄨ嵂鐗╃爺绌跺浗闄呯煡鍚嶆湡鍒奐ournal of Medicinal Chemistry, ChemMedChem, PLOS One绛夋湡鍒婂彂琛⊿CI璁烘枃70浣欑瘒銆

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銆銆浠ｈ〃鎬ц鏂囷細

銆銆1. Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)-ones as Polypharmacological Inhibitors of BET and Kinases. J Med Chem. 2020 Aug 26. doi: 10.1021/acs.jmedchem.0c00962.

銆銆2. Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors. J Med Chem. 2019 Sep 26;62(18):8642-8663.

銆銆3. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J Med Chem. 2019 Jun 13;62(11):5414-5433.

銆銆4. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and in vivo study. Acta Pharm Sin B. 2019 Mar;9(2):351-368.

銆銆5. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.